use of 3-amino-4,6-dimethylpyrazolo[3,4-b]pyridine in the synthesis of novel heterocycles of pharmaceutical interest

• Published in: Chemistry of heterocyclic compounds (New York, N.Y. 1965) Vol. 44; no. 6; pp. 715 - 721
• Main Authors: Metwally, M. A, Etman, H. A, Gafer, H. E, Khalil, A. M
• Format: Journal Article
• Language: English
• Published: Boston Boston : Springer US 01.06.2008; Springer US; Springer Nature
• Subjects: Chemistry; Chemistry and Materials Science; Chemistry, Organic; Organic Chemistry; Pharmacy; Physical Sciences; pyrazolo[4,3-e]pyrido[2',3':3,4]pyrazolo[1,5-a]pyrimidines; pyrido[2',3':3,4]pyrazolo-[1,5-a]pyrimidines; Science & Technology; substituted[3,4-b]pyridines; pyrazolo[4,3; pyridines; pyrimidines; pyrido[2′,3′:3,4]pyrazolo[1,5; pyrido[2′,3′:3,4]pyrazolo-[1,5; substituted[3,4; substituted[3,4-b]pyridines; pyrazolo[4,3-e]pyrido[2 ',3 ':3,4]pyrazolo[1,5-a]pyrimidines; pyrido[2 ',3 ':3,4]pyrazolo-[1,5-a]pyrimidines; IMINES
• ISSN: 0009-3122; 1573-8353
• DOI: 10.1007/s10593-008-0103-8

3-Amino-4,6-dimethylpyrazolo[3,4-b]pyridine was used for the preparation of some novel heterocycles of pharmaceutical interest. The starting material reacted with 2-cyano-3,3-bis(methylthio)acrylate, chloroacetyl chloride, phenyl isothiocyanate, carbon disul-fide, and aromatic aldehydes to give the novel heterocycles. The structures of the hitherto unknown ring systems have been confirmed by analytical and spectral methods.