Photothermal triggered protein release from an injectable polycaprolactone-based microspherical depot

Upon exposure to visible light, controlled multiple dose protein release was demonstrated by using a microspherical depot composed of biodegradable poly(ε-caprolactone) (PCL), bovine serum albumin (BSA) or horseradish peroxidase (HRP) as model protein, polymer-coated gold nanoparticles as phototherm...

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Published inJournal of materials chemistry. B, Materials for biology and medicine Vol. 5; no. 20; pp. 3634 - 3639
Main Authors Ge, Chunling, Basuki, Johan S, White, Jacinta, Hou, Ruixia, Peng, Yong, Hughes, Timothy C, Tan, Tianwei
Format Journal Article
LanguageEnglish
Published England 28.05.2017
Subjects
Biodegradability
Biology
Exposure
Gold
Medicine
Nanoparticles
Peroxidase
Proteins
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Summary:Upon exposure to visible light, controlled multiple dose protein release was demonstrated by using a microspherical depot composed of biodegradable poly(ε-caprolactone) (PCL), bovine serum albumin (BSA) or horseradish peroxidase (HRP) as model protein, polymer-coated gold nanoparticles as photothermal component, which can potentially reduce the number of invasive therapeutic injections.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:2050-750X
2050-7518
DOI:10.1039/c7tb00837f