Photodynamic therapy for residual neoplasms of the perianal skin

• Published in: Diseases of the colon & rectum Vol. 43; no. 4; pp. 499 - 502
• Main Authors: RUNFOLA, M. A, WEBER, T. K, RODRIGUEZ-BIGAS, M. A, DOUGHERTY, T. J, PETRELLI, N. J
• Format: Journal Article
• Language: English
• Published: Secaucus, NJ Springer 01.04.2000
• Subjects: Adult; Aged; Anal Canal - pathology; Anus Neoplasms - drug therapy; Anus Neoplasms - pathology; Biological and medical sciences; Bowen's Disease - drug therapy; Bowen's Disease - pathology; Carcinoma, Squamous Cell - drug therapy; Carcinoma, Squamous Cell - pathology; Diseases of the digestive system; Female; Humans; Male; Medical sciences; Middle Aged; Neoplasm, Residual; Paget Disease, Extramammary - drug therapy; Paget Disease, Extramammary - pathology; Photochemotherapy; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Skin Neoplasms - drug therapy; Skin Neoplasms - pathology; Treatment Outcome; Human; Skin disease; Photodynamic therapy; Perianal; Surgery; Instrumentation therapy; Digestive diseases; Surgical resection; Skin; Combined treatment; Malignant tumor
• ISSN: 0012-3706; 1530-0358
• DOI: 10.1007/BF02237193

The aim of this study was to evaluate the efficacy of photodynamic therapy in the management of residual neoplasms of the perianal skin. This is a retrospective review. Five patients with pathologic confirmation of residual perianal neoplasms were treated with photodynamic therapy. There were three females. The mean age was 52 (range, 33-79) years. Pathology consisted of Bowen's disease in two patients, squamous-cell carcinoma in two patients, and extramammary Paget's disease in one patient. Four patients received one photodynamic therapy treatment and one patient received two treatments three months apart. Treatment was followed by immediate perianal erythema, subsequent blister formation in 36 to 48 hours, and sloughing of the treated area in 72 hours. With a mean follow-up of 5.2 (range, 1-8) years, there were two recurrences. One recurrence was in a patient four years after treatment for Paget's disease, and the other was in a patient nine months after treatment for Bowen's disease. The latter was managed successfully with wide local excision. Treatment-related toxicities included significant perianal pain in four patients, controlled with analgesia management. Photodynamic therapy can successfully be used after wide local excision for residual neoplasms of the perianal skin. Treatment can be rendered with acceptable morbidity.