Pharmacological studies on perazine and its primary metabolites

The study served to answer the question whether metabolites possibly contribute to the clinical actions of the neuroleptic drug perazine. The primary metabolites demethylperazine and perazine sulfoxide were investigated with regard to influences on behavior in mice, to an antiemetic action in dogs,...

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Bibliographic Details
Published inPharmacopsychiatry Vol. 22; no. 6; p. 255
Main Authors Brand, U, Menge, H G, Neumann, B W, Stille, G
Format Journal Article
LanguageEnglish
Published Germany 01.11.1989
Subjects
Animals
Antiemetics
Antipsychotic Agents - pharmacology
Behavior, Animal - drug effects
Blood Pressure - drug effects
Dogs
Female
Male
Mice
Motor Activity - drug effects
Norepinephrine - pharmacology
Perazine - metabolism
Perazine - pharmacology
Psychomotor Performance - drug effects
Rats
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Summary:The study served to answer the question whether metabolites possibly contribute to the clinical actions of the neuroleptic drug perazine. The primary metabolites demethylperazine and perazine sulfoxide were investigated with regard to influences on behavior in mice, to an antiemetic action in dogs, and to a modification of the pressor effect of noradrenaline in rats. In contrast to perazine, none of the metabolites exhibited effects that can be interpreted to indicate neuroleptic or antidepressive properties of the compounds.
ISSN:0176-3679
DOI:10.1055/s-2007-1014610