Oxidative Stress and the Nrf2/PPARγ Axis in the Endometrium: Insights into Female Fertility

Successful pregnancy depends on precise molecular regulation of uterine physiology, especially during the menstrual cycle. Deregulated oxidative stress (OS), often influenced by inflammatory changes but also by environmental factors, represents a constant threat to this delicate balance. Oxidative s...

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Published inCells (Basel, Switzerland) Vol. 13; no. 13; p. 1081
Main Authors Artimovič, Peter, Badovská, Zuzana, Toporcerová, Silvia, Špaková, Ivana, Smolko, Lukáš, Sabolová, Gabriela, Kriváková, Eva, Rabajdová, Miroslava
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 22.06.2024
Subjects
Angiogenesis
Animals
Apoptosis
Blood vessels
cellular signaling
Chemokines
Cytokines
Endometrium
Endometrium - metabolism
Environmental factors
Enzymes
Estrogens
Female
Females
Fertility
Fertility - physiology
Homeostasis
Humans
In vitro fertilization
Infertility
Inflammation
Kinases
Menstrual cycle
Menstruation
Molecular modelling
Morphology
NF-E2-Related Factor 2 - metabolism
Nitric oxide
Nrf2
Ovaries
Ovulation
Oxidative Stress
Peroxisome proliferator-activated receptors
Physiology
Polycystic ovary syndrome
PPAR gamma - metabolism
PPARγ
Signal Transduction
Transcription factors
Nrf2
fertility
cellular signaling
endometrium
mini review
female
PPARγ
oxidative stress
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Summary:Successful pregnancy depends on precise molecular regulation of uterine physiology, especially during the menstrual cycle. Deregulated oxidative stress (OS), often influenced by inflammatory changes but also by environmental factors, represents a constant threat to this delicate balance. Oxidative stress induces a reciprocally regulated nuclear factor erythroid 2-related factor 2/peroxisome proliferator-activated receptor-gamma (Nrf2/PPARγ) pathway. However, increased PPARγ activity appears to be a double-edged sword in endometrial physiology. Activated PPARγ attenuates inflammation and attenuates OS to restore redox homeostasis. However, it also interferes with physiological processes during the menstrual cycle, such as hormonal signaling and angiogenesis. This review provides an elucidation of the molecular mechanisms that support the interplay between PPARγ and OS. Additionally, it offers fresh perspectives on the Nrf2/PPARγ pathway concerning endometrial receptivity and its potential implications for infertility.
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ISSN:2073-4409
2073-4409
DOI:10.3390/cells13131081