Successful treatment of retrograde ejaculation with the α1-adrenergic agonist methoxamine : case study

We treated two patients affected by retrograde ejaculation (RE) with the pure α1-adrenergic agonist methoxamine; the drug was self-administered intramuscularly by the patients 30 min prior to intercourse or masturbation. A previous trial with oral imipramine had been ineffective in both patients. Sp...

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Bibliographic Details
Published inInternational journal of impotence research Vol. 17; no. 3; pp. 297 - 299
Main Authors TOMASI, P. A, FANCIULLI, G, DELITALA, G
Format Journal Article
LanguageEnglish
Published Basingstoke Nature Publishing 01.05.2005
Nature Publishing Group
Subjects
Biological and medical sciences
Birth control
Fertility
Gynecology. Andrology. Obstetrics
Male genital diseases
Medical sciences
Non tumoral diseases
Patients
Pregnancy
Sperm
Sterility. Assisted procreation
Andrology
Agonist
Serotonin
Retrograde
α1-Adrenergic receptor
Catecholamine
Tricyclic compound
Reuptake inhibitor
male infertility
Case study
Pregnancy
Imipramine
Treatment
α-Adrenergic receptor
Ejaculation
Neurotransmitter
Female
Male sterility
Norepinephrine
α-Adrenergic receptor agonist
Methoxamine
retrograde ejaculation
Male genital diseases
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Summary:We treated two patients affected by retrograde ejaculation (RE) with the pure α1-adrenergic agonist methoxamine; the drug was self-administered intramuscularly by the patients 30 min prior to intercourse or masturbation. A previous trial with oral imipramine had been ineffective in both patients. Sperm count increased substantially, particularly in the first patient who had insulin-dependent diabetes and was seeking fertility. In this patient, total ejaculated sperm increased from 22 millions to 488 and 419.5 millions on two different occasions, with good motility; two clinical pregnancies were obtained in the partner of this patient after 3 and 4 months of treatment, respectively. The second patient did not desire fertility. In both patients, no side effects were seen except for slight piloerection; blood pressure values increased slightly, and heart rate was unchanged. We conclude that self-administered methoxamine can be a useful, noninvasive and inexpensive treatment of RE, when oral agents are ineffective.
ISSN:0955-9930
1476-5489
DOI:10.1038/sj.ijir.3901253