Enhancement of mechanical strength and osteogenesis, and inhibition of osteoclastic activity for β-tricalcium phosphate bioceramics by incorporating calcium silicate and magnesium-strontium phosphate
β-tricalcium phosphate bioceramics suffer from a drawback of poor mechanical strength and a scarcity of capacity to regulate biological performances. In the current study, the overall performances of β-tricalcium phosphate (TCP) bioceramics were improved by incorporating calcium silicate (CS) and ma...
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Published in | Ceramics international Vol. 47; no. 17; pp. 24191 - 24197 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Elsevier Ltd
01.09.2021
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Subjects | |
Online Access | Get full text |
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Summary: | β-tricalcium phosphate bioceramics suffer from a drawback of poor mechanical strength and a scarcity of capacity to regulate biological performances. In the current study, the overall performances of β-tricalcium phosphate (TCP) bioceramics were improved by incorporating calcium silicate (CS) and magnesium-strontium phosphate (MSP). During the sintering process, the MSP stabilized the β phase of TCP, and the formation of MSP melt ensured effective liquid-sintering of TCP, thus conducing to lower porosity of TCP/MSP and TCP/CS/MSP bioceramics. In comparison with the TCP bioceramics, the TCP/CS and TCP/MSP bioceramics showed lower compressive strength, while the TCP/CS/MSP bioceramics attained noticeably higher compressive strength. Due to the sustained release of therapeutical ions, the TCP/CS bioceramics enhanced in vitro early-stage osteoblastic differentiation, but compromised cell proliferation; both the TCP/MSP and TCP/CS/MSP bioceramics enhanced cell proliferation and osteoblastic differentiation, and restrained osteoclastic activities. Collectively, the TCP/CS/MSP bioceramics with optimal overall performances are promising for efficaciously treating the defects of osteoporotic bone. |
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ISSN: | 0272-8842 1873-3956 |
DOI: | 10.1016/j.ceramint.2021.05.130 |