Effect of hyperkalemia on insulin secretion

• Published in: Experientia Vol. 47; no. 3; p. 270
• Main Authors: Martinez, R, Rietberg, B, Skyler, J, Oster, J R, Perez, G O
• Format: Journal Article
• Language: English
• Published: Switzerland 15.03.1991
• Subjects: Animals; Blood Glucose - analysis; Dogs; Female; Hyperkalemia - physiopathology; Insulin - metabolism; Insulin Secretion; Male; Potassium - blood

The effect of hyperkalemia on insulin secretion remains undefined. We evaluated portal and peripheral insulin levels in anesthetized dogs after infusions of KCl. The mean maximal increase in peripheral plasma potassium at infusion rates of 0.2 mEq/kg/h was 0.68 +/- 0.20 mEq/l. There were no signific...