Effect of hyperkalemia on insulin secretion

The effect of hyperkalemia on insulin secretion remains undefined. We evaluated portal and peripheral insulin levels in anesthetized dogs after infusions of KCl. The mean maximal increase in peripheral plasma potassium at infusion rates of 0.2 mEq/kg/h was 0.68 +/- 0.20 mEq/l. There were no signific...

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Bibliographic Details
Published inExperientia Vol. 47; no. 3; p. 270
Main Authors Martinez, R, Rietberg, B, Skyler, J, Oster, J R, Perez, G O
Format Journal Article
LanguageEnglish
Published Switzerland 15.03.1991
Subjects
Animals
Blood Glucose - analysis
Dogs
Female
Hyperkalemia - physiopathology
Insulin - metabolism
Insulin Secretion
Male
Potassium - blood
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Summary:The effect of hyperkalemia on insulin secretion remains undefined. We evaluated portal and peripheral insulin levels in anesthetized dogs after infusions of KCl. The mean maximal increase in peripheral plasma potassium at infusion rates of 0.2 mEq/kg/h was 0.68 +/- 0.20 mEq/l. There were no significant increases in either portal or peripheral insulin levels. In contrast, in six dogs whose plasma potassium concentration increased in each case by more than 2.0 mEq/l (infusion rate of 0.5 mEq/kg/h), portal insulin levels increased fivefold (p less than 0.05). We concluded that only marked increases in plasma potassium concentration stimulate pancreatic insulin secretion.
ISSN:0014-4754
DOI:10.1007/BF01958157