In vitro drug interaction studies of atorvastatin with ciprofloxacin, gatifloxacin, and ofloxacin

We describe the in vitro availability of atorvastatin, a potent HMG-CoA reductase inhibitor, in presence of ciprofloxacin, gatifloxacin, and ofloxacin, all with a wide antibacterial spectrum. These studies were performed at 37°C, 48°C, and 60°C in different pH environments, simulating human body com...

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Published inMedicinal chemistry research Vol. 19; no. 8; pp. 717 - 731
Main Authors Arayne, M. Saeed, Sultana, Najma, Rizvi, Syeda Bushra Shakeb, Haroon, Urooj
Format Journal Article
LanguageEnglish
Published Boston Boston : SP Birkhäuser Verlag Boston 01.11.2010
SP Birkhäuser Verlag Boston
Subjects
Atorvastatin
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Charge-transfer complex
ciprofloxacin
Gatifloxacin
Interactions
ofloxacin
Original Research
Pharmacology/Toxicology
Atorvastatin
Charge-transfer complex
Interactions
Ciprofloxacin
Ofloxacin
Gatifloxacin
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Summary:We describe the in vitro availability of atorvastatin, a potent HMG-CoA reductase inhibitor, in presence of ciprofloxacin, gatifloxacin, and ofloxacin, all with a wide antibacterial spectrum. These studies were performed at 37°C, 48°C, and 60°C in different pH environments, simulating human body compartments. The reactions were studied by UV spectroscopy, and the availability of both the drugs in presence of each other was determined by deriving a simultaneous equation for two component system through modification of Beer's law. It has been observed that due to interaction, the availability of both atorvastatin and quinolones increased considerably in nearly all pH mediums, which are attributed to the formation of charge-transfer complexes. The results were further confirmed by IR, HNMR, and mass spectrometric studies.
Bibliography:http://dx.doi.org/10.1007/s00044-009-9225-5
ISSN:1054-2523
1554-8120
DOI:10.1007/s00044-009-9225-5