Long-range macromolecule interaction and “speed reading” long nucleotide sequences in DNA

• Published in: Physics letters. A Vol. 377; no. 3-4; pp. 323 - 328
• Main Authors: Namiot, V.A., Anashkina, A.A., Filatov, I.V., Tumanyan, V.G., Esipova, N.G.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 03.01.2013
• Subjects: Atomic force microscope; DNA sequence; Fast DNA reading; Long-distance interactions; DNA sequence; Fast DNA reading; Long-distance interactions; Atomic force microscope
• ISSN: 0375-9601; 1873-2429
• DOI: 10.1016/j.physleta.2012.11.029

Methods based on the phenomenon of the specific long-range interaction between long macromolecules proposed for “speed reading” nucleotide sequences in single DNA molecules. One way is to measure the electric field potential along the preliminary stretched double DNA strand. Another way of information “reading” is to measure deformation of strand elements caused by an electric field that is generated by the “straightening” electrode due to an alternating voltage applied to it. On the base of the obtained information the sequence of nucleotides in the strand could be determined in principle. ► Proposed new methods for “speed reading” nucleotide sequences of DNA. ► Considered a way to place DNA in the straightened state on a substrate. ► It is shown, how it is possible to stretch DNA and transfer it to S-form. ► Shown a method for measuring the electric potential of charges in the DNA. ► Proposed a way to measure DNA deformations and, by means, DNA sequence.