Chemical enhancers for transdermal drug transport

In its first part, this review paper discusses skin morphology and barrier function of the stratum corneum for drug permeation after its transdermal administration or topical application. Further, the paper presents the main methods for overcoming the skin permeation barrier, which plays an importan...

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Bibliographic Details
Published inEuropean journal of drug metabolism and pharmacokinetics Vol. 26; no. 1-2; pp. 85 - 94
Main Authors BAUEROVA, K, MATUSOVA, D, KASSAI, Z
Format Journal Article
LanguageEnglish
Published Genève Médecine et hygiène 01.01.2001
Subjects
Administration, Cutaneous
Animals
Biological and medical sciences
Biological Transport, Active - drug effects
General pharmacology
Humans
Medical sciences
Pharmaceutical Preparations - metabolism
Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions
Pharmacology. Drug treatments
Skin Absorption - drug effects
Skin Physiological Phenomena - drug effects
Stimulation, Chemical
Human
Drug
Absorption
Animal
Dosage form
Skin
Absorption enhancer
Drug adjuvant
Review
Pharmacokinetics
Percutaneous route
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Summary:In its first part, this review paper discusses skin morphology and barrier function of the stratum corneum for drug permeation after its transdermal administration or topical application. Further, the paper presents the main methods for overcoming the skin permeation barrier, which plays an important role for transdermal drug administration. Focus is on the method of chemical permeation enhancement. The chemical enhancers are categorised by their chemical structure. Examples of the most effective enhancers are given for the chemical groups of alcohols, amines and amides, polyalcohols, terpenes, fatty acids and their esters, macro cyclic compounds, sulfoxides, tensides, and others, as e.g. soft enhancers.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0378-7966
2107-0180
DOI:10.1007/BF03190381