Application of carbon nanotube–ionic liquid–epinephrine composite gel modified electrode as a sensor for glutathione

A sensitive and convenient electrochemical sensor was developed for the determination of glutathione by using a carbon nanotube–ionic liquid–epinephrine composite gel modified electrode. As a mediator, epinephrine exhibited an obvious electrocatalytic activity towards the oxidation of glutathione. T...

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Bibliographic Details
Published inJournal of electroanalytical chemistry (Lausanne, Switzerland) Vol. 757; pp. 198 - 202
Main Authors Liu, Benzhi, Wang, Min, Xiao, Bo
Format Journal Article
LanguageEnglish
Published Elsevier B.V 15.11.2015
Subjects
Carbon nanotube
Electrochemical sensor
Epinephrine
Glutathione
Ionic liquid
Carbon nanotube
Epinephrine
Electrochemical sensor
Glutathione
Ionic liquid
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Summary:A sensitive and convenient electrochemical sensor was developed for the determination of glutathione by using a carbon nanotube–ionic liquid–epinephrine composite gel modified electrode. As a mediator, epinephrine exhibited an obvious electrocatalytic activity towards the oxidation of glutathione. The square wave voltammetric technique was used to detect glutathione. The oxidation peak current showed a linear relationship with the concentration of glutathione in the range of 0.1–3.0μM, with a detection limit of 0.04μM. The repeatability and reproducibility of the sensor were investigated with the relative standard deviation (RSD%) 3.7% and 4.2%, respectively. The proposed sensor was successfully applied for the determination of glutathione in urine sample and tablet. Good recovery of 94%–106% demonstrated the capability of the sensor for the determination of GSH in real samples.
ISSN:1572-6657
1873-2569
DOI:10.1016/j.jelechem.2015.09.034