Efficient solid-phase synthesis of isocytosine derivatives

We have investigated the potential use of a solid-phase synthesis of novel 6-(arylmethyl)-5-methyl-isocytosine derivatives based on the immobilization of the corresponding 2-thiothymine on a Merrifield resin, oxidation of the immobilized form to the sulfone, and aminolysis of the latter under mild c...

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Bibliographic Details
Published inChemistry of heterocyclic compounds (New York, N.Y. 1965) Vol. 45; no. 11; pp. 1365 - 1369
Main Authors Novakov, I. A, Orlinson, B. S, Brunilin, R. V, Nawrozkij, M. B, Gordeeva, E. A, Savel‘ev, E. N, Gerasimov, E. N
Format Journal Article
LanguageEnglish
Published Boston Boston : Springer US 01.11.2009
Springer US
Springer Nature
Subjects
antiviral properties
Chemistry
Chemistry and Materials Science
Chemistry, Organic
isocytosines
Organic Chemistry
Pharmacy
Physical Sciences
Science & Technology
solid-phase synthesis
“addition-elimination” mechanism
isocytosines
antiviral activity
“addition-elimination” mechanism
solid-phase synthesis
POTENT
ANTI-HIV-1 ACTIVITY
"addition-elimination" mechanism
FAMILY
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Summary:We have investigated the potential use of a solid-phase synthesis of novel 6-(arylmethyl)-5-methyl-isocytosine derivatives based on the immobilization of the corresponding 2-thiothymine on a Merrifield resin, oxidation of the immobilized form to the sulfone, and aminolysis of the latter under mild conditions.
Bibliography:http://dx.doi.org/10.1007/s10593-010-0434-0
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-010-0434-0