Effect of L-dopa on visual evoked potentials and neuropsychological tests in adult phenylketonuria patients

Eight adult, untreated patients with classical phenylketonuria received L-dopa and a decarboxylase inhibitor for 2 weeks. No effect of L-dopa therapy on choice reaction time tasks, sustained attention, frontal lobal function as well as latencies of visual evoked potentials was found. The results rai...

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Published inEuropean journal of pediatrics Vol. 155 Suppl 1; no. S1; pp. S74 - S77
Main Authors Ullrich, K, Weglage, J, Oberwittler, C, Pietsch, M, Fünders, B, von Eckardstein, H, Colombo, J P
Format Journal Article
LanguageEnglish
Published Germany Springer Nature B.V 01.07.1996
Subjects
Adult
Attention
Dihydroxyphenylalanine
Dopamine
Evoked potentials
Evoked Potentials, Somatosensory - drug effects
Humans
Laboratories
Levodopa
Levodopa - pharmacology
Levodopa - therapeutic use
Neuropsychological Tests
Neuropsychology
Parkinson's disease
Phenylalanine - blood
Phenylketonuria
Phenylketonurias - blood
Phenylketonurias - drug therapy
Phenylketonurias - physiopathology
Reaction Time - drug effects
Reaction time task
Treatment Outcome
Visual evoked potentials
Visual perception
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Summary:Eight adult, untreated patients with classical phenylketonuria received L-dopa and a decarboxylase inhibitor for 2 weeks. No effect of L-dopa therapy on choice reaction time tasks, sustained attention, frontal lobal function as well as latencies of visual evoked potentials was found. The results raise the question if adult patients with phenylketonuria really suffer from functional dopamine deficiency.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0340-6199
1432-1076
DOI:10.1007/PL00014256