The determination of molecular dynamic properties of Novel 5-oxo-1,2,4-triazole phthalocyanines and investigation of their urease inhibition properties

• Published in: Journal of molecular structure Vol. 1222; p. 128870
• Main Authors: Kaya, Mehmet, MENTEŞE, Emre, SÖKMEN, Bahar BİLGİN, AKÇAY, Hakkı Türker
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 15.12.2020
• Subjects: Aggregation; Fluorescence; Phthalocyanine; Urease inhibition activity; Aggregation; Fluorescence; Phthalocyanine; Urease inhibition activity
• ISSN: 0022-2860; 1872-8014
• DOI: 10.1016/j.molstruc.2020.128870

•Synthesis and characterization of novel 5-oxo-1,2,4-triazole phthalocyanine complexes.•The investigation of urease inhibition activities of the synthesized compounds.•The determination of molecular dynamic properties of novel phthalocyanines. In present study, the novel peripherally [3-methyl-5-oxo-4-(4-phenoxyphenyl)-4,5-dihydro-1H-1,2,4-triazol-1-yl] substituted Zn(II), Cu(II), Co(II) phthalocyanines were synthesized and characterized spectroscopically. The light absorption/emission behavior of the synthesized phthalocyanines were determined by UV-Vis and fluorescence spectroscopy. The fluorescence quantum yields of the novel phthalocyanine Zn(II) complex in different solvents were calculated. Besides, the urease inhibition activities of the novel compounds were investigated. All synthesized phthalocyanines have a superior inhibitory activity on urease enzyme, while novel phthalocyanines Cu(II) showed the best inhibitory effect against jack bean urease with IC50 values of 0.0035 ±0.0010 µM. [Display omitted]