Eighteen-Week Exercise and Nutritional Education Program Did Not Modify the Serum Levels of sVCAM-1 and sCD40-L in Subjects with Metabolic Syndrome

• Published in: Laboratory medicine Vol. 41; no. 4; pp. 231 - 234
• Main Authors: González, Iván Palomo, Madariaga, Elba Leiva, Avíles, Carlos Reyes, Lozano, Marcelo Alarcon, Escudero, Veronica Mujica, Sanzana, Nora Díaz, Noguera, Gloria Icaza, Rojas, Marcela Vásquez, Moore-Carrasco, Rodrigo
• Format: Journal Article
• Language: English
• Published: Chicago Oxford University Press 01.04.2010
• Subjects: Cell adhesion & migration; Cytokines; Exercise; Intervention; Metabolic syndrome; Nutrition education
• ISSN: 0007-5027; 1943-7730
• DOI: 10.1309/LMXK8V3R4FEPFVKK

Some cell adhesion molecules increase their serum concentration in the Metabolic Syndrome (MS); among them the sVCAM-1 and sCD40-L surpass their physiopathological importance. Such molecules are associated with endothelium and platelet activation, respectively, and an increase at their serum level can partially provide information on the endothelium damage and platelet activation in individuals with MS. The purpose of this study was to evaluate the effect of an intervention with physical activity and nutrition education on the serum levels of sVCAM-1 and sCD40L. The study included 50 non-smoking men and women, between the ages of 39 and 62 years old. All of them had MS as defined by the National Cholesterol Education Program (NCEP). The subjects were randomly separated into the following 2 groups: (a) intervened MS (I-MS, n=27), who participated in the intervention based on exercise for 18 weeks and lectures about nutrition education, and (b) non-intervened MS (NI-MS, n=24), as a control group. All of the participants' basal and final times were determined (18 weeks), the serum concentration of soluble Vascular Cell Adhesion Molecule-1 (sVCAM-1), sCD40L, and some anthropometric and biochemical parameters. The non-pharmacologic intervention did not modify the serum levels of sVCAM-1: I-MS group (basal: medium 674 [interquartile range 270] versus final: 641 [240] ng/mL); NI-MS group (basal: 643 [252] and final: 597 [197] ng/mL) (interaction P=0.190). The non-pharmacologic intervention applied to the I-MS group did not modify the serum levels of sCD40-L (basal: 219 [265] versus final: 183.5 [162] pg/mL). However, an increase in the serum levels of sCD40-L in the NI-MS group was observed (basal: 155.5 [142] and final 359.5 [112] pg/mL) (interaction P=0.007). When the serum levels of the studied molecules with the MS critena variables were studied, a significant positive correlation between sCD40-L and waist circumference was observed (P=0.045). The results of the present study show that a physical activity intervention program of only 18 weeks does not reduce the serum levels of sVCAM-1 and sCD40-L. [PUBLICATION ABSTRACT]