Disaccharide nucleosides and oligonucleotides on their basis. New tools for the study of enzymes of nucleic acid metabolism

The main structural features of an important group of natural compounds, disaccharide nucleosides, are reviewed. The synthesis and properties of modified oligonucleotides on their basis as well as the methods of introduction of reactive aldehyde groups are described. The last part is devoted to the...

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Bibliographic Details
Published inBiochemistry (Moscow) Vol. 67; no. 10; pp. 1136 - 1144
Main Authors Efimtseva, E V, Mikhailov, S N
Format Journal Article
LanguageEnglish
Published United States Springer Nature B.V 01.10.2002
Subjects
Aldehydes - metabolism
Base Sequence
Deoxyribonucleic acid
Disaccharides - chemistry
Disaccharides - metabolism
DNA
Enzymes - metabolism
Nucleic acids
Nucleic Acids - chemistry
Nucleic Acids - metabolism
Nucleosides - chemical synthesis
Nucleosides - chemistry
Nucleosides - metabolism
Oligonucleotides - chemistry
Oligonucleotides - metabolism
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Summary:The main structural features of an important group of natural compounds, disaccharide nucleosides, are reviewed. The synthesis and properties of modified oligonucleotides on their basis as well as the methods of introduction of reactive aldehyde groups are described. The last part is devoted to the application of these compounds for studies of enzymes of nucleic acid metabolism.
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ISSN:0006-2979
1608-3040
DOI:10.1023/A:1020963207320