Brown Seaweed Byproduct Extracts Improve Intestinal Motility and Auto-Inflammation in Mice with Loperamide-Induced Constipation

• Published in: Foods Vol. 13; no. 13; p. 2037
• Main Authors: Koh, Eun-Jeong, Shin, Kwang-Soon, Sunwoo, In Yung, Kim, Junseong, Choi, Woon-Yong
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 27.06.2024
• Subjects: Algae; Bacteria; Byproducts; Carbohydrates; Constipation; Dietary fiber; Digestive system; Digestive tract; Feces; Food; Food processing; Functional foods & nutraceuticals; Gastric motility; Immunoglobulins; Inflammation; Intestinal microflora; Intestinal motility; Intestine; Laboratory animals; Landfills; Mannuronic acid; Manufacturers; Microbiota; Microorganisms; Motility; Nutritive value; Oral administration; Phenols; Polysaccharides; Saccharides; Sargassum fulvellum; Sargassum fusiforme; seaweed byproducts; Seaweeds; Tumor necrosis factor-TNF; Waste disposal; Waste disposal sites; United States > US; South Korea; Japan; constipation; seaweed byproducts; intestinal motility; Sargassum fusiforme; inflammation; Sargassum fulvellum
• ISSN: 2304-8158; 2304-8158
• DOI: 10.3390/foods13132037

and are types of brown algae used for their nutritional value and medicinal properties, including anti-inflammatory, antioxidant, and anticancer effects. Despite their importance in various industries, many seaweed byproducts containing dietary fiber and polysaccharides are discarded in landfills. These byproducts can be recycled and repurposed for different applications. In this study, we investigated the impact of food processing byproducts (MbP-SFF) and food processing byproducts (MbP-SFV) on improving intestinal motility and reducing inflammation in mice with constipation induced by loperamide. To evaluate this, mice were orally administered 500 mg/kg/day of the byproducts once daily for 8 days. Constipation was induced by 5 mg/kg/day of loperamide for two days after oral administration for 6 days. Each sample contained approximately 70% carbohydrates. MbP-SFF had 52.0% mannuronic acid and 18.8% guluronic acid, while MbP-SFV had 36.9% mannuronic acid and 32.9% guluronic acid. These byproducts enhanced fecal excretion and intestinal motility by modulating inflammatory responses. Furthermore, they restored the balance of the gut microbiota disrupted by loperamide, increasing beneficial and reducing harmful . Overall, MbP-SFF and MbP-SFV improved intestinal motility and inflammation by influencing the gut microbiota and inflammatory responses in a loperamide-induced mouse model. These byproducts show potential as ingredients in functional foods aimed at enhancing gut health, potentially reducing waste disposal costs and addressing environmental concerns associated with their utilization.