Sanwei sandalwood decoction ameliorates acute ischemia reperfusion injury in rats by modulating myocyte electrophysiological characteristics

• Published in: Biomedicine & pharmacotherapy Vol. 158; p. 114103
• Main Authors: Wan, Quan, Wang, Yu, Yong, Ming, Hu, PengFei, Le Liang, Che Ge, Yang, Xiang Jun, Zhao, Xiao, San, Dan, Bai, Ting Ting, Tong, La Ga, Zhai, Jingbo, Zhao, Ming, Zhang, QingShan
• Format: Journal Article
• Language: English
• Published: Elsevier 01.02.2023
• Subjects: Electrophysiological characteristics; Ischemia/reperfusion injury; Sanwei sandalwood decoction
• ISSN: 0753-3322
• DOI: 10.1016/j.biopha.2022.114103

Sanwei sandalwood decoction (SWTX) is a classical Chinese medicine formula and clinically effective treatment for coronary heart disease, including myocardial ischemia/reperfusion (I/R) injury. Because the treatment mechanism of SWTX in I/R injury remains obscure, we intended to analyze the potential cardioprotective effects of SWTX in rats with myocardial I/R injury. Our research revealed that SWTX prolonged ventricular conduction time in a dose-dependent manner. While SWTX significantly delayed left ventricular signal conduction velocity, it had no effect on left atrial conduction velocity. Under sinus conditions, low SWTX concentrations reduced left ventricular conduction dispersion, while high concentrations increased conduction dispersion. SWTX also prolonged the QRS interval, APD30/50/90, and ERP. In whole-cell patch clamp experiments on myocytes, Ito and Ikr were inhibited by SWTX. While SWTX had no effect on INa, the activation curve for Nav1.5 was left-shifted. Finally, SWTX reduced the probability of ventricular fibrillation and suppressed early and late depolarization in an acute I/R injury rat model. These findings shed light on the mechanism by which SWTX alleviates myocardial I/R injury.