Long-Term Efficacy of Poly(L-lactide-co-ε-caprolactone) Copolymer Lifting Threads with Encapsulated MICROscale Hyaluronic Acid Particles Using NAMICA Technology: Investigating Biorevitalizing Effects in Skin Remodeling (Part 1)

• Published in: Cosmetics (Basel) Vol. 12; no. 1; p. 20
• Main Authors: Burko, Pavel, Sulamanidze, George, Nikishin, Dmitriy
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.01.2025
• Subjects: Anesthesia; Animal models; biorevitalization; Clinical trials; Collagen; Females; Hyaluronic acid; lifting threads; Medicine; Microencapsulation; Molecular weight; non-surgical facelift; Performance evaluation; Polymerization; Skin; skin remodeling; Ultrasonic imaging; Georgia; United States > US; Tbilisi Georgia (country); Georgia (country)
• ISSN: 2079-9284; 2079-9284
• DOI: 10.3390/cosmetics12010020

Facial thread lifting with absorbable threads such as poly(L-lactide-co-ε-caprolactone) (P(LA/CL)) has been explored in an animal model. This experimental study utilized P(LA/CL)-HA-micro threads enhanced with hyaluronic acid microencapsulation via NAMICA technology in five four-month-old female pigs. The effects were compared to those of P(LA/CL)-HA threads over a six-month period through histological analysis. The results indicated improvements in skin remodeling, with P(LA/CL)-HA-micro threads enabling controlled and prolonged release of hyaluronic acid, leading to sustained improvements in tissue structure. These findings suggest that microencapsulated threads could enhance therapeutic outcomes; however, these results are preliminary and derived from an animal model. Further research and clinical trials are necessary to confirm these benefits in human subjects.