COVID-19 Infection and Neuropathological Features

The pathology associated with COVID-19 infection is progressively being revealed. Recent postmortem assessments have revealed acute airway inflammation as well as diffuse alveolar damage, which bears resemblance to severe acute respiratory syndromes induced by both SARS-CoV and MERS-CoV infections....

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Published inMedicines (Basel, Switzerland) Vol. 8; no. 10; p. 59
Main Authors Freire-de-Lima, Leonardo, Scovino, Aline Miranda, Marques da Fonseca, Leonardo, Barreto Menezes, Camilla Cristie, Santos, Carlos Antonio do Nascimento, Freire de Lima, Marco Edilson, Decote-Ricardo, Debora, Freire-de-Lima, Matheus, da Costa, Kelli Monteiro, dos Reis, Jhenifer Santos, Rodrigues da Costa Santos, Marcos André, Freire-de-Lima, Celio Geraldo, Morrot, Alexandre
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 11.10.2021
MDPI
Subjects
autoantibodies
Coronaviruses
COVID-19
COVID-19 infection
neuroinflammation
neuropathology
Opinion
Parkinson's disease
Viral infections
China
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Summary:The pathology associated with COVID-19 infection is progressively being revealed. Recent postmortem assessments have revealed acute airway inflammation as well as diffuse alveolar damage, which bears resemblance to severe acute respiratory syndromes induced by both SARS-CoV and MERS-CoV infections. Although recent papers have highlighted some neuropathologies associated with COVID-19 infection, little is known about this topic of great importance in the area of public health. Here, we discuss how neuroinflammation related to COVID-19 could be triggered by direct viral neuroinvasion and/or cytokine release over the course of the infection.
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These authors contributed equally to this work.
ISSN:2305-6320
2305-6320
DOI:10.3390/medicines8100059