Early ileal resection in Crohn's disease is not associated with severe long‐term outcomes: The ERIC study

• Published in: Alimentary pharmacology & therapeutics Vol. 60; no. 10; pp. 1388 - 1397
• Main Authors: Grellier, Nathan, Kirchgesner, Julien, Uzzan, Mathieu, Mclellan, Paul, Stefanescu, Carmen, Lefèvre, Jérémie H., Treton, Xavier, Panis, Yves, Sokol, Harry, Beaugerie, Laurent, Seksik, Philippe
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.11.2024; Wiley
• Subjects: Adult; Crohn Disease - surgery; Crohn's disease; Crohns disease; Diagnosis; Female; Human health and pathology; Humans; Hépatology and Gastroenterology; Ileum - pathology; Ileum - surgery; Inflammatory bowel diseases; Life Sciences; Male; Medical treatment; Middle Aged; Morphology; Patients; Recurrence; Reoperation - statistics & numerical data; Retrospective Studies; Surgery; Time Factors; Treatment Outcome; Young Adult; Crohn 's disease; Surgery; IBD
• ISSN: 0269-2813; 1365-2036; 1365-2036
• DOI: 10.1111/apt.18247

Summary Background Early complicated Crohn's disease (CD) may require ileal resection as first‐line treatment. Aim To evaluate the long‐term outcomes of patients who underwent early ileal resection. Methods We conducted a retrospective study in two inflammatory bowel diseases (IBD) referral centres, including patients with ileocaecal resection and segmental ileal resection within 5 years of CD diagnosis. Early resection was defined as within 6 months of diagnosis, intermediate resection between 6 months and 2 years, and late resection between 2 and 5 years. The primary outcome was the cumulative risk of a second ileal surgery. Secondary outcomes included the use of postoperative treatments and morphological recurrence after initial surgery (Rutgeerts score ≥i2, or recurrence on imaging). Results Among 393 patients who underwent ileal resection within 5 years of diagnosis, 130, 128 and 135, respectively, had early, intermediate and late resection. The cumulative risk of second surgery at 10 years was not significantly different in the early resection group (25.0% [95% CI 17.4–35.2]), than the intermediate (16.8% [95% CI 10.5–26.2]; p = 0.17) or late resection group (22.7% [95% CI 15.1–33.3]; p = 0.83). The early resection group required fewer postoperative treatments than the late resection group with median survivals without treatments of 3.7 and 0.9 years, respectively (p = 0.002). Patients who had early resection had significantly less morphological recurrence than the late resection group (p = 0.02). Conclusion Early ileal resection in CD is not associated with a higher risk of a second resection. It may be associated with reduced use of medical treatments and fewer morphological recurrences. Early ileal resection for Crohn's disease within the first 6 months of diagnosis is not associated with a higher risk of re‐resection compared with late resection. On the contrary, patients who undergo early resection may require fewer postoperative treatments and have less evidence of disease recurrence on endoscopy and imaging.