Genotoxic evaluation of the effect of Thuya occidentalys tinctures

Three tinctures samples from extracts of the popular medicinal plant Thuya occidentalis were tested in vitro through two short term tests for measuring the activity of genotoxic chemicals. Using the Salmonella/mammalian-microsome (Mutatest) assay and the SOS-chromotest (induction of beta-galactosida...

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Bibliographic Details
Published inBrazilian journal of biology Vol. 61; no. 2; pp. 329 - 332
Main Authors Valsa, J O, Felzenszwalb, I
Format Journal Article
LanguageEnglish
Published Brazil Instituto Internacional de Ecologia 01.05.2001
Subjects
BIOLOGY
Coloring Agents - toxicity
Escherichia coli - drug effects
Mutagenicity Tests - methods
Plant Extracts - toxicity
Salmonella typhimurium - drug effects
SOS Response (Genetics)
Salmonella
teste de Ames
Thuya occidentalis
popular medicine
medicina popular
SOS-cromoteste
SOS-chromotest
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Summary:Three tinctures samples from extracts of the popular medicinal plant Thuya occidentalis were tested in vitro through two short term tests for measuring the activity of genotoxic chemicals. Using the Salmonella/mammalian-microsome (Mutatest) assay and the SOS-chromotest (induction of beta-galactosidase in Escherichia coli), none of the extract was effective in inducing mutagenesis or beta-galactosidase synthesis (as an indicator of general and early sign of DNA damage), even with metabolization.
ISSN:1519-6984
0034-7108
0034-7108
DOI:10.1590/s0034-71082001000200017