How to improve the survival of the fetal ventral mesencephalic cell transplanted in Parkinson's disease?

It has been extensively confirmed that fetal ventral mesencephalic cell (VMC) transplantation can ameliorate the symptoms of Parkinson's disease (PD). But there are still several problems to be resolved before the extensive clinical application of this technology. The major limitations are the...

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Bibliographic Details
Published inNeuroscience bulletin Vol. 23; no. 6; pp. 377 - 382
Main Authors Liu, Jia, Huang, Hong-Yun
Format Journal Article
LanguageEnglish
Published Singapore Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences 01.11.2007
Subjects
Animals
Brain Tissue Transplantation - methods
Fetal Stem Cells - transplantation
Fetal Tissue Transplantation - methods
Graft Survival
Humans
Mesencephalon - embryology
Mesencephalon - transplantation
Minireview
Parkinson Disease - therapy
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Summary:It has been extensively confirmed that fetal ventral mesencephalic cell (VMC) transplantation can ameliorate the symptoms of Parkinson's disease (PD). But there are still several problems to be resolved before the extensive clinical application of this technology. The major limitations are the poor survival of grafted dopamine (DA) neurons and restricted dopaminergic reinnervation of host striatum. Some attempts have been made to solve these problems including use of some trophic factor and co-transplantation with neural/paraneural origins. The purpose of this review is to overview advances of the means improving the survival of grafts and their current limitations.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1673-7067
1995-8218
DOI:10.1007/s12264-007-0056-4