C−H Alkylation of N‐Benzyl Anilines via Visible‐Light‐Driven 1,5‐Hydrogen Atom Transfer (1,5‐HAT) of Hydroxamic Acid Derivatives

• Published in: Advanced synthesis & catalysis Vol. 366; no. 21; pp. 4436 - 4440
• Main Authors: Li, Yuanyuan, Liu, Xingyu, Lv, Guanghui, Xu, Yanning, Ye, Meiling, Chen, Jian, Hou, Jinyu, Guo, Li, Yang, Zhongzhen, Wu, Yong
• Format: Journal Article
• Language: English
• Published: Heidelberg Wiley Subscription Services, Inc 05.11.2024
• Subjects: 1,5-hydrogen atom transfer; Alkylation; Aniline; Functional groups; Hydrogen atoms; Hydroxamic acid derivatives; Nitrogen; Photo-catalysis; Radical reactions; Substitutes

Here we reported the photo‐catalyzed C−H alkylation of pyridyl‐substituted N‐benzyl anilines through nitrogen‐centred radical 1,5‐hydrogen atom transfer. A broad range of methylpyridyl‐substituted aniline and hydroxylamine acid derivatives were successfully transformed into the corresponding product...