C−H Alkylation of N‐Benzyl Anilines via Visible‐Light‐Driven 1,5‐Hydrogen Atom Transfer (1,5‐HAT) of Hydroxamic Acid Derivatives

Here we reported the photo‐catalyzed C−H alkylation of pyridyl‐substituted N‐benzyl anilines through nitrogen‐centred radical 1,5‐hydrogen atom transfer. A broad range of methylpyridyl‐substituted aniline and hydroxylamine acid derivatives were successfully transformed into the corresponding product...

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Published inAdvanced synthesis & catalysis Vol. 366; no. 21; pp. 4436 - 4440
Main Authors Li, Yuanyuan, Liu, Xingyu, Lv, Guanghui, Xu, Yanning, Ye, Meiling, Chen, Jian, Hou, Jinyu, Guo, Li, Yang, Zhongzhen, Wu, Yong
Format Journal Article
LanguageEnglish
Published Heidelberg Wiley Subscription Services, Inc 05.11.2024
Subjects
1,5-hydrogen atom transfer
Alkylation
Aniline
Functional groups
Hydrogen atoms
Hydroxamic acid derivatives
Nitrogen
Photo-catalysis
Radical reactions
Substitutes
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Summary:Here we reported the photo‐catalyzed C−H alkylation of pyridyl‐substituted N‐benzyl anilines through nitrogen‐centred radical 1,5‐hydrogen atom transfer. A broad range of methylpyridyl‐substituted aniline and hydroxylamine acid derivatives were successfully transformed into the corresponding products in moderate yields without adding any base and metal. This protocol features mild reaction conditions, a broad range of substrates, remarkable functional group tolerance and simple operation procedure.
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ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202400642