ILC2s in Virus-induced Asthma Exacerbations: A Starring or Supportive Role?

Hershenson discusses the study by Dhariwal and colleagues on the role of ILC2s in virus-induced asthma exacerbations, which is published within the issue. The team measured nasal and BAL cytokines and ILC2s in control subjects and subjects with asthma before and after nasal challenge with rhinovirus...

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Bibliographic Details
Published inAmerican journal of respiratory and critical care medicine Vol. 204; no. 11; pp. 1239 - 1240
Main Author Hershenson, Marc B.
Format Journal Article
LanguageEnglish
Published United States American Thoracic Society 01.12.2021
Subjects
Allergies
Asthma
Flow cytometry
Humans
Immunity, Innate
Lymphocytes
Steroids
Th2 Cells
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Summary:Hershenson discusses the study by Dhariwal and colleagues on the role of ILC2s in virus-induced asthma exacerbations, which is published within the issue. The team measured nasal and BAL cytokines and ILC2s in control subjects and subjects with asthma before and after nasal challenge with rhinovirus A16 (7). Patients with asthma were required to have a doctor diagnosis, treatment with inhaled corticosteroids, airways hyperresponsiveness by bronchoconstrictor challenge testing, and evidence of atopy on skin prick testing. ILC populations were identified by flow cytometry. The results establish ILC2s as a likely mediator of viral-induced exacerbations in patients with allergic asthma.
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ISSN:1073-449X
1535-4970
1535-4970
DOI:10.1164/rccm.202108-2001ED