Tacrolimus in steroid-resistant and steroid-dependent nephrotic syndrome

• Published in: Clinical nephrology Vol. 65; no. 6; p. 393
• Main Authors: Westhoff, T H, Schmidt, S, Zidek, W, Beige, J, van der Giet, M
• Format: Journal Article
• Language: English
• Published: Germany 01.06.2006
• Subjects: Adult; Blood Glucose - analysis; Blood Pressure - drug effects; Blood Proteins - analysis; Creatinine - urine; Drug Resistance; Drug Therapy, Combination; Female; Glomerulosclerosis, Focal Segmental - drug therapy; Humans; Male; Middle Aged; Nephrosis, Lipoid - drug therapy; Nephrotic Syndrome - drug therapy; Prednisolone - therapeutic use; Proteinuria - drug therapy; Steroids - pharmacology; Steroids - therapeutic use; Tacrolimus - therapeutic use
• ISSN: 0301-0430
• DOI: 10.5414/cnp65393

Steroid resistance and steroid dependence constitute a major problem in the treatment of minimal-change disease and focal segmental glomerulosclerosis (FSGS). Cyclophosphamide and cyclosporine are well-established alternative immunomodulating agents, whereas data on FK 506 (tacrolimus) are rare. The present work provides data from 10 patients of an open, monocentric, non-randomized, prospective trial. Five patients with steroid-dependent minimal-change nephrotic syndrome, 1 patient with steroid-refractory minimal-change disease and 4 patients with steroid-refractory FSGS were started on tacrolimus at trough levels of 5 10 microg/l. In case of steroid-dependence, prednisolone was tapered off in presence oftacrolimus within one month. Within 6 months, complete remission was achieved in 5 patients (50%) and partial remission in 4 patients (40%), yielding a final response rate of 90%. One patient was primarily resistent to tacrolimus (steroid-refractory minimal-change), another patient became secondarily resistant to tacrolimus after an initial remission (steroid-refractory FSGS). Average proteinuria significantly decreased by 77% from 9.5 +/- 1.4 - 2.2 +/- 1.1 g/day (p < 0.01). Serum protein significantly raised from 55.0 +/- 1.9 - 64.6 +/- 1.9 g/l (p < 0.01). Tacrolimus induced non-significant increases of blood glucose (4.9 +/- 0.1 - 5.1 +/- 0.2 mmol/l), systolic blood pressure (131.4 +/- 7.1 - 139.0 +/- 7.6 mmHg) and creatinine (93.2 +/- 13.9 103.2 +/- 15.3 mmol/l). Five patients have been tapered off tacrolimus so far, nephrotic syndrome relapsed in 4 of them (80%). Relapse occurred at tacrolimus levels between 2.6 and 6.9 ng/ml. Our data suggest that tacrolimus may be a promising alternative to cyclosporine both in steroid-resistant and steroid-dependent nephrotic syndrome.