CATHODIC STRIPPING VOLTAMMETRY OF THE ANTIHYPERTENSIVE DRUG CAPTOPRIL IN BOTH AQUEOUS AND BIOLOGICAL MEDIA

Adsorptive stripping voltammetry is used for determination of trace levels of captopril in phosphoric acid (pH 2.3). The adsorptive peak was observed at −0.49 V vs. Ag/AgCl. The peak response was characterized with respect to pH, preconcentration time, possible interferences, deposition potential, s...

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Bibliographic Details
Published inAnalytical letters Vol. 35; no. 2; pp. 239 - 256
Main Authors Ghandour, M. A., Kasim, Ensaf Aboul, El-Haty, M. T., Ahmed, Mahasen M.
Format Journal Article
LanguageEnglish
Published Philadelphia, PA Taylor & Francis Group 13.02.2002
Taylor & Francis
Subjects
Analysis
Biological and medical sciences
Captopril
Cathodic stripping voltammetry
Determn
General pharmacology
Linear sweep
Medical sciences
Pharmacology. Drug treatments
Trace analysis
Imidazole derivatives
Biological fluid
Phosphoric acid
Chemical analysis
Electrolyte solution
Captopril
Interelement effect
Electrochemical method
Enzyme inhibitor
Cathodic stripping voltammetry
Sample preparation
Dosage form
Antihypertensive agent
ACE inhibitor
Quantitative analysis
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Summary:Adsorptive stripping voltammetry is used for determination of trace levels of captopril in phosphoric acid (pH 2.3). The adsorptive peak was observed at −0.49 V vs. Ag/AgCl. The peak response was characterized with respect to pH, preconcentration time, possible interferences, deposition potential, supporting electrolytes and other variables. The obtained results were analyzed and the statistical parameters were calculated. Also the method was applied to determine the mentioned drug in pharmaceutical formulations, urine and blood-serum. The limit of detection was 0.019 ng/ml.
ISSN:0003-2719
1532-236X
DOI:10.1081/AL-120002527