Discovery of hydroxamate as a promising scaffold dually inhibiting metallo- and serine-β-lactamases

• Published in: European journal of medicinal chemistry Vol. 265; p. 116055
• Main Authors: Wu, Xiao-Rong, Chen, Wei-Ya, Liu, Lu, Yang, Ke-Wu
• Format: Journal Article
• Language: English
• Published: ISSY-LES-MOULINEAUX Elsevier Masson SAS 05.02.2024; Elsevier
• Subjects: Antibiotic resistance; Chemistry, Medicinal; Hydroxamate; Inhibitor; Life Sciences & Biomedicine; Metallo-β-lactamase; Pharmacology & Pharmacy; Science & Technology; Serine-β-lactamase; Metallo-β-lactamase; Inhibitor; Hydroxamate; Serine-β-lactamase; Antibiotic resistance; ANTIBIOTICS; DESIGN; Metallo; PROTEIN; Serine; CRYSTAL-STRUCTURE; KLEBSIELLA-PNEUMONIA; SILVER NANOPARTICLES; IN-VITRO; PURIFICATION; beta-lactamase

The bacterial infection mediated by β-lactamases MβLs and SβLs has grown into an emergent health threat, however, development of a molecule that dual inhibits both MβLs and SβLs is challenging. In this work, a series of hydroxamates 1a-g, 2a-e, 3a-c, 4a-c were synthesized, characterized by 1H and 13...