Effect of perindopril and bisoprolol on IL-2, INF-γ, hs-CRP and T-cell stimulation and correlations with blood pressure in mild and moderate hypertension

• Published in: International journal of clinical pharmacology and therapeutics Vol. 56; no. 9; pp. 393 - 399
• Main Authors: Madej, Andrzej, DÄ bek, Józefa, Majewski, Michał, Szuta, Justyna
• Format: Journal Article
• Language: English
• Published: Germany Dustri - Verlag Dr. Karl Feistle GmbH & Co. KG 01.09.2018
• Subjects: Adrenergic beta-1 Receptor Antagonists - therapeutic use; Adult; Angiotensin-Converting Enzyme Inhibitors - therapeutic use; Antihypertensive Agents - therapeutic use; Antihypertensives; Arterial Pressure - drug effects; Biomarkers - blood; Bisoprolol - therapeutic use; Blood pressure; Body mass index; C-Reactive Protein - metabolism; Cardiology; Cardiovascular disease; Case-Control Studies; Cytokines; Female; Health sciences; High density lipoprotein; Humans; Hypertension; Hypertension - blood; Hypertension - diagnosis; Hypertension - drug therapy; Hypertension - physiopathology; Inflammation; Interferon-gamma - blood; Interleukin-2 - blood; Lymphocyte Activation - drug effects; Lymphocytes; Male; Middle Aged; Pathogenesis; Perindopril - therapeutic use; Severity of Illness Index; Statistical analysis; T-Lymphocytes - drug effects; T-Lymphocytes - immunology; T-Lymphocytes - metabolism; Time Factors; Treatment Outcome
• ISSN: 0946-1965
• DOI: 10.5414/CP203249

Cardiovascular disease is the leading global cause of death. Its development is largely determined by lifestyle and cardiovascular risk factors, among which arterial hypertension (HT) plays a key role. Available data indicate a significant role of inflammation in the pathophysiology of HT. The aim of this study was to assess concentrations of mediators of inflammation in patients with mild and moderate HT and its modulation with antihypertensive treatment. 56 subjects: 17 with first- and 20 with second-grade HT, and 19 healthy subjects constituting a control group. Antihypertensive therapy: in first-grade HT, perindopril 5 mg daily, and in second-grade HT, bisoprolol (5 mg daily) additionally were ordered. Before and after a 4-week treatment, interleukine-2, interferon-γ, and high-sensitivity C-reactive protein serum concentrations were assessed. hs-CRP concentration was higher in hypertensive patients, and the difference was statistically significant in patients with second-grade HT compared to the control group (1.42 mg/L vs. 2.55 mg/L; p = 0.003). Antihypertensive treatment was associated with hs-CRP decrease. IL-2 concentration was 14.8% (p = 0.005) higher in first- and 22.2% (p = 0.002) higher in second-grade HT compared to the controls. Treatment significantly reduced concentration of IL-2. IFN-γ concentrations, compared to the control group, were higher by 19.6% (p < 0.001) and 39.9% (p < 0.001) in 1st and 2nd grade HT, respectively. Increased values of blood pressure were accompanied by higher concentrations of cytokines and hs-CRP. Reversal of adverse T-cell stimulation was observed after 4-week therapy.
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