Quantitative EEG and prognosis for recovery in post-stroke patients: The effect of lesion laterality

• Published in: Neurophysiologie clinique Vol. 54; no. 3; p. 102952
• Main Authors: Liuzzi, Piergiuseppe, Grippo, Antonello, Sodero, Alessandro, Castagnoli, Chiara, Pellegrini, Ilaria, Burali, Rachele, Toci, Tanita, Barretta, Teresa, Mannini, Andrea, Hakiki, Bahia, Macchi, Claudio, Lolli, Francesco, Cecchi, Francesca
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.05.2024
• Subjects: Aged; Aged, 80 and over; Brain - physiopathology; Brain symmetry; Electroencephalography - methods; Female; Functional Laterality - physiology; Humans; Male; Middle Aged; Neurorehabilitation; Prognosis; Quantitative EEG; Recovery of Function - physiology; Stroke; Stroke - complications; Stroke - physiopathology; Stroke Rehabilitation - methods; Quantitative EEG; Stroke; Neurorehabilitation; Brain symmetry
• ISSN: 0987-7053; 1769-7131
• DOI: 10.1016/j.neucli.2024.102952

There is emerging confidence that quantitative EEG (qEEG) has the potential to inform clinical decision-making and guide individualized rehabilitation after stroke, but consensus on the best EEG biomarkers is needed for translation to clinical practice. This study investigates the spatial qEEG spectral and symmetry distribution in patients with a left/right hemispheric stroke, to evaluate their side-specific prognostic power in post-acute rehabilitation outcome. Resting-state 19-channel EEG recordings were collected with clinical information on admission to intensive inpatient rehabilitation (within 30 days post stroke), and six months post stroke. After preprocessing, spectral (Delta-to-Alpha Ratio, DAR) and symmetry (pairwise and hemispheric Brain Symmetry Index) features were extracted. Patients were divided into Affected Right and Left (AR/AL) groups, according to the location of their lesion. Within each group, DAR was compared between homologous electrode pairs and the pairwise difference between pairs was compared across pairs in the scalp. Then, the prognostic power of qEEG admission metrics was evaluated by performing correlations between admission metrics and discharge mBI values. Fifty-two patients with hemorrhagic or ischemic stroke (20 females, 38.5 %, median age 76 years [IQR = 22]) were included in the study. DAR was significantly higher in the affected hemisphere for both AR and AL groups, and, a higher frontal (to posterior) asymmetry was found independent of the side of the lesion. DAR was found to be a prognostic marker of 6-months modified Barthel Index (mBI) only for the AL group, while hemispheric asymmetry did not correlate with follow-up outcomes in either group. While the presence of EEG abnormalities in the affected hemisphere of a stroke is well recognized, we have shown that the extent of DAR abnormalities seen correlates with disability at 6 months post stroke, but only for left hemispheric lesions. Routine prognostic evaluation, in addition to motor and functional scales, can add information concerning neuro-prognostication and reveal neurophysiological abnormalities to be assessed during rehabilitation.