Frequency of hereditary nonpolyposis colorectal cancer in southern Alberta

The frequency of hereditary nonpolyposis colorectal cancer was evaluated in a group of colorectal cancer patients under age 50 diagnosed in southern Alberta between 1973 and 1987. Families were identified as positive for this syndrome if three first-degree relatives in the kindred had colorectal can...

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Bibliographic Details
Published inDigestive diseases and sciences Vol. 36; no. 10; p. 1441
Main Authors Westlake, P J, Bryant, H E, Huchcroft, S A, Sutherland, L R
Format Journal Article
LanguageEnglish
Published United States 01.10.1991
Subjects
Adenocarcinoma - epidemiology
Adolescent
Adult
Aged
Alberta - epidemiology
Anus Neoplasms - epidemiology
Colorectal Neoplasms - epidemiology
Colorectal Neoplasms - genetics
Colorectal Neoplasms - mortality
Colorectal Neoplasms - pathology
Family
Female
Humans
Incidence
Male
Middle Aged
Neoplasm Staging
Neoplasms, Second Primary
Pedigree
Survival Rate
Alberta
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Summary:The frequency of hereditary nonpolyposis colorectal cancer was evaluated in a group of colorectal cancer patients under age 50 diagnosed in southern Alberta between 1973 and 1987. Families were identified as positive for this syndrome if three first-degree relatives in the kindred had colorectal cancer. Of the 390 patients with adenocarcinoma, 318 patients participated. The frequency of hereditary nonpolyposis colorectal cancer was 3.1% (12 families) in this group (Ci95 1.6-5.3%). Clinical characteristics reported on from the index patients include tumor location, Dukes stage at presentation, frequency of synchronous and metachronous tumors, frequency of second primaries, and survival. The 5- and 10-year actuarial survival was 86% and 69%, respectively.
ISSN:0163-2116
DOI:10.1007/BF01296813