Increasing the antinociceptive effect of ingested glycinamide in female rats by increasing its palatability

•Glycinamide-in-chocolate suspension induced antinociception in two nociceptive tests.•Glycinamide induced antinociception most likely by increasing glycine levels. These studies were undertaken to investigate whether the ingestion of glycinamide, a precursor of glycine, made more palatable by mixin...

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Published inNeuroscience letters Vol. 737; p. 135314
Main Authors Gómora-Arrati, Porfirio, González-Flores, Oscar, Morales-Medina, Julio César, Komisaruk, Barry
Format Journal Article
LanguageEnglish
Published Ireland Elsevier B.V 15.10.2020
Subjects
Analgesia
Analgesics - pharmacology
Animals
antinociception
Chocolate
Female
glycinamide ingestion
glycine
Glycine - analogs & derivatives
Glycine - pharmacology
Nociception - drug effects
Pain Measurement - drug effects
Pain Threshold - drug effects
Rats
Rats, Sprague-Dawley
Spinal Cord - drug effects
Taste - physiology
antinociception
glycine
glycinamide ingestion
chocolate
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Summary:•Glycinamide-in-chocolate suspension induced antinociception in two nociceptive tests.•Glycinamide induced antinociception most likely by increasing glycine levels. These studies were undertaken to investigate whether the ingestion of glycinamide, a precursor of glycine, made more palatable by mixing with a chocolate suspension, improves antinociception in rats. Two nociception threshold models were employed: the tail-flick latency and vocalization to tail shock, in restricted and freely-moving rats. Glycinamide in a highly palatable commercial chocolate aqueous suspension was provided for ad-lib ingestion after 24 hours of water deprivation. Antinociception threshold testing was performed before and 10, 30, 60, 90, 120, 180, and 240 minutes after the ingestion of the chocolate-glycinamide mixture. Ingestion of the glycinamide-in-chocolate suspension induced antinociception based on the tail shock vocalization and tail-flick latency tests. Ingestion of the glycinamide-in-chocolate suspension induced an 80% elevation in the antinociceptive threshold that persisted for 4 hours. Rats readily ingest the glycine precursor, glycinamide, in an aqueous chocolate mixture, which induces potent and prolonged antinociception.
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ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2020.135314