Growth-hormone releasing factor does not antagonize somatostatin effects on pancreatic and gastric secretions

The effect of human GRF 44 upon somatostatin-inhibited pancreatic and gastric secretions was studied in rats with chronic fistulas. GRF did not show any antagonist action of somatostatin on these gastro-intestinal organs. GRF alone had a small inhibitory effect on gastric acid output.

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Bibliographic Details
Published inExperientia Vol. 41; no. 11; p. 1451
Main Authors Chovet, M, Dubrasquet, M, Chariot, J, Rozé, C
Format Journal Article
LanguageEnglish
Published Switzerland 15.11.1985
Subjects
Animals
Bicarbonates - metabolism
Gastric Acid - metabolism
Growth Hormone-Releasing Hormone - pharmacology
Kinetics
Male
Pancreas - drug effects
Pancreas - metabolism
Peptide Fragments - pharmacology
Rats
Rats, Inbred Strains
Somatostatin - antagonists & inhibitors
Somatostatin - pharmacology
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Summary:The effect of human GRF 44 upon somatostatin-inhibited pancreatic and gastric secretions was studied in rats with chronic fistulas. GRF did not show any antagonist action of somatostatin on these gastro-intestinal organs. GRF alone had a small inhibitory effect on gastric acid output.
ISSN:0014-4754
DOI:10.1007/BF01950030