Anti-inflammatory, anti-diabetic, and biocompatibility properties of aqueous extract of Tamarindus indica L. fruit coat analyses by in-vitro and in-vivo approaches

• Published in: Environmental research Vol. 251; no. Pt 2; p. 118702
• Main Authors: Kathirvel, Brindhadevi, AlSalhi, Mohamad S., Ha, Hai-Anh, Nguyen-Thi, Thai-Hang
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 15.06.2024
• Subjects: Animals; Anti-inflammatory; Anti-Inflammatory Agents - chemistry; Anti-Inflammatory Agents - pharmacology; Antidiabetic; Antioxidants - chemistry; Antioxidants - pharmacology; Female; Fruit - chemistry; Fruit coat; Hypoglycemic Agents - chemistry; Hypoglycemic Agents - pharmacology; Male; Mice; Plant Extracts - chemistry; Plant Extracts - pharmacology; Serum marker; Tamarindus - chemistry; Tamarindus indica L; Serum marker; Tamarindus indica L; Fruit coat; Anti-inflammatory; Antidiabetic
• ISSN: 0013-9351; 1096-0953; 1096-0953
• DOI: 10.1016/j.envres.2024.118702

The anti-inflammatory, anti-diabetic, and biocompatibility nature of Tamarindus indica L. fruit coat aqueous extract were investigated in this research through in-vitro and in-vivo studies. The anti-inflammatory property was determined through albumin denaturation inhibition and antiprotease activities as up to 39.5% and 41.2% respectively at 30 mg mL−1 concentration. Furthermore, the antidiabetic activity was determined through α-amylase and α-glucosidase inhibition as up to 62.15% and 67.35% respectively at 30 mg mL−1 dosage. The albino mice based acute toxicity study was performed by different treatment groups (group I–V) with different dosages of aqueous extract to detect the biocompatibility of sample. Surprisingly, findings revealed that the T. indica L. fruit coat aqueous extract had no harmful impacts on any of the groups. Urine, as well as serum parameter analysis, confirmed this. Moreover, the findings of SOD (Superoxide Dismutase), GST (Glutathione-S-transferase), & CAT (Catalase) as well as glutathione peroxidase as well as reduced glutathione antioxidant enzymes studies stated that the aqueous extract possess high antioxidant ability via a dose-dependent way. These findings indicate that T. indica fruit coat aqueous extract contains medicinally important phytochemicals with anti-inflammatory and anti-diabetic properties, as well as being biocompatible in nature. [Display omitted] •Aqueous extract of T. indica fruit coat possess fine biomedical applications.•T. indica aqueous extract had fine anti-inflammatory activity at 30 mg mL−1 dosage.•Aqueous extract also possess dose dependent antidiabetic activity (67.35%).•Albino mice based study proved that the aqueous extract is biocompatible in nature.•Animal model study also evidenced that aqueous extract also had antioxidant activity.