Synthesis of a dendritic estrogen cluster： A potential tool for studies of nuclear versus extranuclear pathways of estrogen actions

A novel estrogen dendrimer has been synthesized through a combination of divergent and convergent approaches in 9 practical steps and in good yields. It was characterized and confirmed by elemental analysis, FT-IR, MS, 1H NMR, 13C NMR. The dendrimer contains 16 estrone units and is potentially a use...

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Bibliographic Details
Published inChinese chemical letters Vol. 23; no. 12; pp. 1319 - 1322
Main Authors Chen, Jian, Zheng, Hu, Song, Yan, Liang, Yu Feng, Qi, Qing Rong
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.12.2012
Functional Food (Drug)Laboratory, Institute of Agro-Product Processing Science and Technology, Sichuan Academy of Agricultural Science, Chengdu 610066, China%Key Laboratory of Drug-Targeting and Drug-Delivery Systems of the Ministry of Education, Department of Medicinal Chemistry,West China School of Pharmacy, Sichuan University, Chengdu 610041, China
Subjects
Estrogen dendrimer
FT-IR
Nuclear and extranuclear
Receptor
Synthesis
合成
工具
树枝状大分子
树突
核外电子
集群
雌激素
Synthesis
Estrogen dendrimer
Nuclear and extranuclear
Receptor
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Summary:A novel estrogen dendrimer has been synthesized through a combination of divergent and convergent approaches in 9 practical steps and in good yields. It was characterized and confirmed by elemental analysis, FT-IR, MS, 1H NMR, 13C NMR. The dendrimer contains 16 estrone units and is potentially a useful tool for the studies of estrogen actions.
Bibliography:11-2710/O6
Estrogen dendrimer; Synthesis; Nuclear and extranuclear; Receptor
A novel estrogen dendrimer has been synthesized through a combination of divergent and convergent approaches in 9 practical steps and in good yields. It was characterized and confirmed by elemental analysis, FT-IR, MS, 1H NMR, 13C NMR. The dendrimer contains 16 estrone units and is potentially a useful tool for the studies of estrogen actions.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2012.11.009