Comparative metabolism of albendazole and albendazole sulphoxide by different helminth parasites

• Published in: Parasitology research (1987) Vol. 87; no. 4; pp. 275 - 280
• Main Authors: SOLANA, H. D, RODRIGUEZ, J. A, LANUSSE, C. E
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01.04.2001
• Subjects: Albendazole - analogs & derivatives; Albendazole - metabolism; Animals; Anthelmintics - metabolism; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiparasitic agents; Ascaris suum - metabolism; Biochemistry. Physiology. Immunology. Molecular biology; Biological and medical sciences; Cestoda - metabolism; Cytosol - metabolism; Fasciola hepatica - metabolism; Fundamental and applied biological sciences. Psychology; Helminthiasis, Animal - parasitology; Invertebrates; Medical sciences; Microsomes - metabolism; Nemathelminthia. Plathelmintha; Oxidation-Reduction; Pharmacology. Drug treatments; Physiology. Development; Sheep; Sheep Diseases - parasitology; Swine; Swine Diseases - parasitology; Host parasite relation; Anthelmintic; Interspecific comparison; Sulfur oxide; Plathelmintha; Parasite; Parasitosis; Microsome; Metabolism; Cytosol; Helminthiasis; Trematoda; Infection; Fasciola hepatica; Albendazole; Benzimidazole derivatives; Parasiticid; Helmintha; Ascaris suum; Nemathelminthia; Invertebrata; Nematoda
• ISSN: 0932-0113; 1432-1955
• DOI: 10.1007/PL00008578

Albendazole (ABZ) is a broad-spectrum benzimidazole anthelmintic widely used in human and veterinary medicine. The aim of the current work was to characterise the sulphoxidative metabolism of ABZ, and the sulphoreduction of ABZ sulphoxide (ABZSO), by microsomal (Ms) and cytosolic (Cyt) fractions of three different helminth species: Fasciola hepatica, Moniezia expansa and Ascaris suum. After the incubation assays, parasite material was analysed by HPLC to characterise the metabolic product formed. Both the Ms and Cyt fractions of the three parasites studied were able to oxidise ABZ into ABZSO in a non-enantioselective fashion. Oxidation of ABZ was greater in the Ms fraction of the trematode (50%) than in both cestode (19%) and nematode (14%) parasites. Only the incubation of ABZSO with both subcellular fractions of M. expansa generated ABZ as a metabolic product. The results obtained here indicate that helminths have the capacity to biotransform benzimidazole compounds; however, this metabolic activity differs qualitatively and quantitatively among helminth species.