Localization and function of myocardial lipolysis

Mobilization of triacylglycerol stored in heart cells is accomplished by the combined action of lysosomal (acid) lipase and microsomal monoacylglycerol lipase or carboxylesterase. Non(heparin)-releasable neutral or alkaline lipase is similar to non(readily)-releasable lipoprotein lipase (LPL). The e...

Full description

Saved in:
Bibliographic Details
Published inBasic research in cardiology Vol. 79; no. 3; p. 268
Main Authors Hülsmann, W C, Stam, H, Jansen, H
Format Journal Article
LanguageEnglish
Published Germany 01.05.1984
Subjects
Animals
Calcium - metabolism
Extracellular Space - enzymology
Glycerol - metabolism
Lipase - metabolism
Lipolysis
Lipoprotein Lipase - metabolism
Lysosomes - enzymology
Microscopy, Electron
Microsomes - enzymology
Monoacylglycerol Lipases - metabolism
Myocardium - enzymology
Rats
Triglycerides - metabolism
Online AccessGet more information

Cover

More Information
Summary:Mobilization of triacylglycerol stored in heart cells is accomplished by the combined action of lysosomal (acid) lipase and microsomal monoacylglycerol lipase or carboxylesterase. Non(heparin)-releasable neutral or alkaline lipase is similar to non(readily)-releasable lipoprotein lipase (LPL). The enzyme is mainly localized extracellularly. Non(readily)-releasable LPL probably represents LPL in caveola or vacuolae of vascular endothelium and/or LPL on myocardial interstitium. It contributes to the uptake of lipoprotein constituents in heart cells. Glycerol, an endproduct of lipolysis, is not a reliable marker for the net mobilization of lipid stored in heart cells. It is formed both intra- and extracellularly, and does not reflect the rate of oxidation of part of free fatty acids formed.
ISSN:0300-8428
DOI:10.1007/BF01908026