Cellular proliferation at sutured and sutureless colonic anastomoses

Elevated cellular proliferation in the vicinity of an anastomosis may explain the enhanced susceptibility to carcinogens. The aim of this study was to determine whether anastomotic cellular proliferation was altered by different suture materials and whether a rise in cell turnover also occurred afte...

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Bibliographic Details
Published inDiseases of the colon & rectum Vol. 36; no. 5; p. 468
Main Authors McCue, J L, Phillips, R K
Format Journal Article
LanguageEnglish
Published United States 01.05.1993
Subjects
Anastomosis, Surgical - adverse effects
Anastomosis, Surgical - methods
Animals
Cell Division
Colon - pathology
Colon - surgery
Colonic Neoplasms - etiology
Insect Proteins
Male
Polyglactin 910
Proteins
Rats
Rats, Inbred F344
Risk Factors
Silk
Stainless Steel
Sutures
Time Factors
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Summary:Elevated cellular proliferation in the vicinity of an anastomosis may explain the enhanced susceptibility to carcinogens. The aim of this study was to determine whether anastomotic cellular proliferation was altered by different suture materials and whether a rise in cell turnover also occurred after a "sutureless" closure. A transverse descending colon enterotomy was repaired with interrupted sutures of 5/0 silk (n = 20), stainless steel (n = 20), or Vicryl (Ethicon, Inc., Somerville, NJ) (n = 20) or by a sutureless technique (n = 20). Using a stathmokinetic technique, crypt cell production rates (CCPR) were calculated at the anastomosis and in the adjacent colon at varying intervals between one week and six months after treatment. Overall colonic cellular proliferation appeared to be elevated at a sutured colotomy for at least three months (P < 0.05). In contrast, no significant elevation in cellular proliferation was observed at sutureless anastomoses. The duration of elevated proliferative response varied among the sutures.
ISSN:0012-3706
DOI:10.1007/BF02050013