Effects of Forssman antibody on renal function of the guinea pig

When guinea pigs were injected with rabbit anti-sheep red blood cell antiserum (Forssman antibody) by the intra arterial (i.a.) route (abdominal aorta at the level of the renal arteries), they developed renal disfunction. A diminished glomerular filtration rate associated with a 27% increase in the...

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Bibliographic Details
Published inResearch in experimental medicine Vol. 187; no. 6; p. 407
Main Authors Barbosa, J E, Sarti, W, Mello, G B
Format Journal Article
LanguageEnglish
Published Germany 01.01.1987
Subjects
Animals
Antibodies, Heterophile - administration & dosage
Glomerular Filtration Rate
Guinea Pigs
Kidney Diseases - etiology
Kidney Diseases - immunology
Kidney Diseases - physiopathology
Male
Potassium - metabolism
Renal Circulation
Sodium - metabolism
Water - metabolism
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Summary:When guinea pigs were injected with rabbit anti-sheep red blood cell antiserum (Forssman antibody) by the intra arterial (i.a.) route (abdominal aorta at the level of the renal arteries), they developed renal disfunction. A diminished glomerular filtration rate associated with a 27% increase in the fractional excretion of K+ was observed. No alterations were noted in the fractional excretion of water and NA+.
ISSN:0300-9130
DOI:10.1007/BF01852178