Unraveling the regulatory landscape of Parkinson disease: A molecular symphony of miRNAs, transcription factors, and high-risk genes

• Published in: Neuroscience letters Vol. 832; p. 137792
• Main Authors: Zameer, Farhan, Jain, Pratheek, Khan, Kounaina, Pramod Kumar, P., Harish Prashanth, K.V., Niranjan, Vidya, Ravish, H.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 29.05.2024
• Subjects: ChIP-seq; Epigenetics; In-silico Biology; miRNA; Network Pharmacology; Personalized medicine; Epigenetics; ChIP-seq; miRNA; In-silico Biology; Personalized medicine; Network Pharmacology
• ISSN: 0304-3940; 1872-7972
• DOI: 10.1016/j.neulet.2024.137792

[Display omitted] •miRNAs as Central Regulators: Regulate multiple high-risk genes associated with PD.•Brain-Centric Expression: High presence of miRNA in the brain, particularly in regions relevant to PD.•Involvement in Vital Pathways: Intricately involved in essential metabolic and signaling pathways.•Gene Expression Patterns: high-risk PD genes in various brain regions (substantia nigra) with emphasis on spatial dynamics.•Comprehensive Regulatory Network: Shedding light on the intricate web of molecular regulation in PD. MicroRNAs (miRNAs) have emerged as critical regulators of post-transcriptional gene expression, impacting various biological processes (development, differentiation, and progression). In medicine, miRNAs are promising diagnostic biomarkers for neurodegenerative diseases, including Parkinson's disease (PD). The current study aims at exploring the role of miRNAs and transcription factors (TFs) in regulating genes-associated with PD. Deploying bioinformatics tools, the study identifies specific miRNAs and TFs involved in PD and their potential connections to the organ-disease junction. Notably, certain miRNAs are found to be highly expressed in brain, than compared to blood. Furthermore, the study explores the expression patterns of PD-related genes in different regions of the brain and attempts to construct complex network of interactions contributing to PD pathogenesis. Additionally, the regulatory relationship of two miRNAs namely hsa-miR-375-3p and hsa-miR-423-3p with TFs are well examined. Overall, the study provides a comprehensive moon-shot view of the molecular aspects of PD and their potential therapeutic targets which could be further used as diagnostic biomarkers in early detection, drug design and development attributing towards precision medicine.