Six new quassinoids from Picrasma chinese P·Y. Chen and their cytotoxicity activity

• Published in: Fitoterapia Vol. 177; p. 106094
• Main Authors: Yang, Quan-Yu, Pu, Xia, Chen, Chan, Zeb, Muhammad Aurang, Tu, Wen-Chao, Li, Hong-Liang, Li, Xiao-Li, Xiao, Wei-Lie
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2024
• Subjects: Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; Cell Line, Tumor; Cytotoxicity activity; Humans; Molecular Structure; Phytochemicals - isolation & purification; Phytochemicals - pharmacology; Picrasma - chemistry; Picrasma chinese P.Y. Chen; Plant Leaves - chemistry; Plant Stems - chemistry; Quassinoids; Quassins - chemistry; Quassins - isolation & purification; Quassins - pharmacology; Picrasma chinese P.Y. Chen; Quassinoids; Cytotoxicity activity
• ISSN: 0367-326X; 1873-6971
• DOI: 10.1016/j.fitote.2024.106094

In the present study, six new compounds namely, picralactones CH (1–6) along with nine known compounds (7–15) were isolated from the branches and leaves of Picrasma chinese P.Y. Chen. Their structures were determined with the help of spectroscopic techniques such as NMR, HR-ESI-MS, UV, IR and CD. Cytotoxicity of all compounds was evaluated against MDA-MB-231, SW-620 and HepG2 human cancer cell lines. Compound 4 showed cytotoxic activities. [Display omitted] •Six new quassinoids were isolated from the branches and leaves of Picrasma chinese P.Y. Chen.•Cytotoxicity of all compounds was evaluated against MDA-MB-231, SW-620 and HepG2 human cancer cell lines.•Compound 4 showed cytotoxic activities.