Mild and Direct Access to 7-Substituted-4-trifluoromethylpyrimido[1,2-b]pyridazin-2-one Systems

New and efficient methods for the synthesis of 7-substituted-4-trifluoromethylpyrimido[1,2-b]pyridazin-2-one derivatives using either two-step Suzuki/heterocyclization, or two-step heterocyclization/substitution sequences are developed. A variety of substituted products are obtained in good to excel...

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Bibliographic Details
Published inSynthesis (Stuttgart) Vol. 46; no. 7; pp. 947 - 954
Main Authors Petrignet, Julien, Thiery, Emilie, Silpa, Laurence, Abarbri, Mohamed
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 01.04.2014
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
aminopyridazine
trifluoromethylpyrimido[1,2-b]pyridazin-2-one
ethyl 4,4,4-trifluorobutynoate
CHEMISTRY
heterocyclization
FLUORINE
INHIBITORS
Suzuki reaction
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Summary:New and efficient methods for the synthesis of 7-substituted-4-trifluoromethylpyrimido[1,2-b]pyridazin-2-one derivatives using either two-step Suzuki/heterocyclization, or two-step heterocyclization/substitution sequences are developed. A variety of substituted products are obtained in good to excellent yields from 3-amino-6-chloropyridazine and ethyl 4,4,4-trifluorobut-2-ynoate.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0033-1340664