Effect of metabolic factors and blood pressure on kidney function in proteinuric type 2 (non-insulin-dependent) diabetic patients

Decline of kidney function with time and its influencing factors were investigated in the present longitudinal study in Type 2 (non-insulin-dependent) diabetic patients with clinical diabetic nephropathy. Compared to a control group of Type 2 diabetic patients without proteinuria, the proteinuric pa...

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Bibliographic Details
Published inDiabetologia Vol. 36; no. 10; p. 1051
Main Authors Hasslacher, C, Bostedt-Kiesel, A, Kempe, H P, Wahl, P
Format Journal Article
LanguageEnglish
Published Germany 01.10.1993
Subjects
Adult
Aged
Blood Glucose - metabolism
Blood Pressure
Body Mass Index
Cholesterol - blood
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - physiopathology
Diabetes Mellitus, Type 2 - urine
Diabetic Nephropathies - blood
Diabetic Nephropathies - physiopathology
Diabetic Nephropathies - urine
Diabetic Retinopathy - epidemiology
Diabetic Retinopathy - physiopathology
Diastole
Female
Glycated Hemoglobin A - analysis
Humans
Male
Middle Aged
Prevalence
Proteinuria
Retrospective Studies
Systole
Triglycerides - blood
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Summary:Decline of kidney function with time and its influencing factors were investigated in the present longitudinal study in Type 2 (non-insulin-dependent) diabetic patients with clinical diabetic nephropathy. Compared to a control group of Type 2 diabetic patients without proteinuria, the proteinuric patients showed a higher prevalence of hypertension, higher systolic blood pressure values and serum triglyceride levels. The annual loss of glomerular kidney function was much higher in the proteinuric patients (5.3 ml.min-1 x 1.73 m2) than in the control subjects (0.9 ml.min-1 x 1.73 m2). Correlation analyses revealed a close correlation between the annual decrease of kidney function and the factors, systolic and diastolic blood pressure, triglyceride and postprandial blood glucose level as well as body mass index. Regression analyses showed for the first time that in addition to the systolic blood pressure and metabolic control, the triglyceride level is also an independent factor influencing the progression of nephropathy. Higher values of these parameters were associated with a more rapid deterioration of kidney function.
ISSN:0012-186X
DOI:10.1007/BF02374498