H-Y transplantation antigen in human XO females

When sensitized with human cultured fibroblasts of the XY and XO, but not XX, sex chromosomal types C57BL/6 female mice reject syngeneic male grafts accelerated (second set graft reaction). These findings demonstrate that the antigenic determinants of H-Y antigen of man and mouse are homologous and...

Full description

Saved in:
Bibliographic Details
Published inHuman genetics Vol. 69; no. 1; p. 15
Main Author Wiberg, U H
Format Journal Article
LanguageEnglish
Published Germany 1985
Subjects
Animals
Cells, Cultured
Chromosome Mapping
Female
Fibroblasts - immunology
Genes
Graft Rejection
H-Y Antigen - genetics
H-Y Antigen - immunology
Humans
Immunization
Male
Mice
Mice, Inbred C57BL
Turner Syndrome - genetics
Turner Syndrome - immunology
Online AccessGet more information

Cover

More Information
Summary:When sensitized with human cultured fibroblasts of the XY and XO, but not XX, sex chromosomal types C57BL/6 female mice reject syngeneic male grafts accelerated (second set graft reaction). These findings demonstrate that the antigenic determinants of H-Y antigen of man and mouse are homologous and that XO females (at least those tested) carry the H-Y transplantation antigen. The results are discussed in the light of the question of differences between the H-Y antigen as defined by grafting and serology and the chromosomal localization of the H-Y structural gene(s).
ISSN:0340-6717
1432-1203
DOI:10.1007/BF00295522