Mechanical, bioactive, and long-lasting antibacterial properties of a Ti scaffold with gradient pores releasing iodine ions

• Published in: Biomaterials advances Vol. 158; p. 213781
• Main Authors: Gallab, Mahmoud, Le, Phuc Thi Minh, Shintani, Seine A, Takadama, Hiroaki, Ito, Morihiro, Kitagaki, Hisashi, Matsushita, Tomiharu, Honda, Shintaro, Okuzu, Yaichiro, Fujibayashi, Shunsuke, Yamaguchi, Seiji
• Format: Journal Article
• Language: English
• Published: Netherlands 01.04.2024
• Subjects: Selective laser melting; Mechanical properties; Antibacterial activity; Apatite; Biocompatibility; Gradient pores; Iodine
• ISSN: 2772-9508; 2772-9508
• DOI: 10.1016/j.bioadv.2024.213781

The ideal bone implant would effectively prevent aseptic as well as septic loosening by minimizing stress shielding, maximizing bone ingrowth, and preventing implant-associated infections. Here, a novel gradient-pore-size titanium scaffold was designed and manufactured to address these requirements. The scaffold features a larger pore size (900 μm) on the top surface, gradually decreasing to small sizes (600 μm to 300 μm) towards the center, creating a gradient structure. To enhance its functionality, the additively manufactured scaffolds were biofunctionalized using simple chemical and heat treatments so as to incorporate calcium and iodine ions throughout the surface. This unique combination of varying pore sizes with a biofunctional surface provides highly desirable mechanical properties, bioactivity, and notably, long-lasting antibacterial activity. The target mechanical aspects, including low elastic modulus, high compression, compression-shear, and fatigue strength, were effectively achieved. Furthermore, the biofunctional surface exhibits remarkable in vitro bioactivity and potent antibacterial activity, even under conditions specifically altered to be favorable for bacterial growth. More importantly, the integration of small pores alongside larger ones ensures a sustained high release of iodine, resulting in antimicrobial activity that persisted for over three months, with full eradication of the bacteria. Taken together, this gradient structure exhibits obvious superiority in combining most of the desired properties, making it an ideal candidate for orthopedic and dental implant applications.