The association of cytokines genes (IL-6 and IL-10) with the susceptibility to schizophrenia: A systematic review and meta-analysis

• Published in: Brain research Vol. 1822; p. 148667
• Main Authors: Beatriz González-Castro, Thelma, Alfonso Tovilla-Zárate, Carlos, Esther Juárez-Rojop, Isela, Hernández-Díaz, Yazmín, Lilia López-Narváez, María, Felicita Ortiz-Ojeda, Rosa
• Format: Journal Article
• Language: English
• Published: Netherlands 01.01.2024
• Subjects: Cytokines - genetics; Genetic Predisposition to Disease - genetics; Humans; Interleukin-10 - genetics; Interleukin-6 - genetics; Polymorphism, Single Nucleotide - genetics; Schizophrenia - genetics; Inflammation; Association; Pathogenesis; Polymorphism
• ISSN: 0006-8993; 1872-6240
• DOI: 10.1016/j.brainres.2023.148667

Cytokines are among the important effectors and messenger molecules for restoring the homeostasis tissue after an inflammatory response. The association between IL-6 and IL-10 genes polymorphisms with the schizophrenia susceptibility have yielded controversial results. To reconcile the results, a systematic review followed by meta-analysis was performed to assess the association. We carried out literature searches of PubMed, Scopus, EBSCO, and Web of Sciences databases. Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated to assess the strength of the association. Subgroup analysis, heterogeneity analyses, and publication bias were also calculated in the meta-analysis. A total of 22 case-control studies, consisting of 4,993 schizophrenic patients and 5,195 healthy controls, were included in the meta-analysis. The meta-analysis suggests that the IL-6 rs1800795 polymorphism displays a protective role against schizophrenia, while the IL-10 rs1800896 and rs1800872 polymorphisms confer an increased risk of schizophrenia. Similar results were found in subgroup analysis by ethnicity. We did not find association between IL-10 rs1800871 polymorphism and schizophrenia susceptibility. Finally, this meta-analysis suggested that the dysregulation of cytokines could lead to the pathogenesis of the schizophrenia.