Expression of tenascin in perifollicular connective tissue: comparison of normal scalp and alopecia areata

Tenascin, a recently discovered extracellular matrix protein, was demonstrated in perifollicular connective tissue of normal human scalp using immunohistochemistry. Its localization was different from other well-known extracellular matrix components, like fibronectin, laminin and heparan sulphate pr...

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Bibliographic Details
Published inArchives of dermatological research Vol. 283; no. 2; p. 86
Main Authors van Baar, H M, Perret, C M, van Vlijmen-Willems, I M, Cleutjens, J P, Mackie, E J, Happle, R, Schalkwijk, J
Format Journal Article
LanguageEnglish
Published Germany 01.01.1991
Subjects
Alopecia Areata - metabolism
Alopecia Areata - pathology
Cell Adhesion Molecules, Neuronal - metabolism
Connective Tissue - metabolism
Extracellular Matrix Proteins - metabolism
Fibronectins - metabolism
Hair - cytology
Hair - metabolism
Hair - pathology
Heparitin Sulfate - metabolism
Humans
Immunohistochemistry
Laminin - metabolism
Scalp - cytology
Scalp - metabolism
Tenascin
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Summary:Tenascin, a recently discovered extracellular matrix protein, was demonstrated in perifollicular connective tissue of normal human scalp using immunohistochemistry. Its localization was different from other well-known extracellular matrix components, like fibronectin, laminin and heparan sulphate proteoglycan. A comparison between alopecia areata and normal scalps did not reveal major qualitative differences, except for an increased expression near heavily infiltrated follicles.
ISSN:0340-3696
DOI:10.1007/BF00371614